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1

CYTOKINES IN RHEUMATOID ARTHRITIS : IS TNFα OF HAAJOR IMPORTANCE?

Marc Feldmann, Fionula M. Brennan, Ravinder N. Maini

Journal:

Clinical & Experimental Allergy

Year:

1993

Language:

english

File:

PDF, 44 KB

english, 1993

2

CD40 LIGATION INDUCES MACROPHAGE IL-10 AND TNF-α PRODUCTION: DIFFERENTIAL USE OF THE PI3K AND p42/44 MAPK-PATHWAYS

Andrew D. Foey, Marc Feldmann, Fionula M. Brennan

Journal:

Year:

2001

Language:

english

File:

PDF, 378 KB

english, 2001

3

ROUTE OF MONOCYTE DIFFERENTIATION DETERMINES THEIR CYTOKINE PRODUCTION PROFILE: CD40 LIGATION INDUCES INTERLEUKIN 10 EXPRESSION

Andrew D Foey, Marc Feldmann, Fionula M Brennan

Journal:

Year:

2000

Language:

english

File:

PDF, 147 KB

english, 2000

4

Cytokines and anti-cytokine biologicals in autoimmunity: present and future

Evangelos T Andreakos, Brian M Foxwell, Fionula M Brennan, Ravinder N Maini, Marc Feldmann

Journal:

Cytokine & Growth Factor Reviews

Year:

2002

Language:

english

File:

PDF, 411 KB

english, 2002

5

Review series Evidence that cytokines play a role in rheumatoid arthritis

Brennan, Fionula M, Mcinnes, Iain B

Year:

2008

Language:

english

File:

PDF, 950 KB

english, 2008

6

TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells

Debra M. Butler, Bernie Scallon, Anthony Meager, Maija Kissonerghis, Anne Corcoran, Yuti Chernajovsky, Marc Feldmann, John Ghrayeb, Fionula M. Brennan

Journal:

Year:

1994

Language:

english

File:

PDF, 908 KB

english, 1994

7

Treatment of rheumatoid tenosynovitis with cytokine inhibitors

Abhilash Jain, Fionula Brennan, Jagdeep Nanchahal

Journal:

Year:

2002

Language:

english

File:

PDF, 65 KB

english, 2002

8

Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model

Sacre, Sandra, Lo, Alexandra, Gregory, Bernard, Stephens, Matthew, Chamberlain, Giselle, Stott, Philip, Brennan, Fionula

Journal:

European Journal of Immunology

Year:

2016

Language:

english

File:

PDF, 997 KB

english, 2016

9

TNF is here to stay!

Fran Balkwill, Brian Foxwell, Fionula Brennan

Journal:

Immunology Today

Year:

2000

Language:

english

File:

PDF, 173 KB

english, 2000

10

Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor

Ching Li, Paul Beavis, Andrew C. Palfreeman, Parisa Amjadi, Alan Kennedy, Fionula M. Brennan

Journal:

Year:

2011

Language:

english

File:

PDF, 302 KB

english, 2011

11

Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions

Fionula Mary Brennan, Andrew David Foey

Journal:

Arthritis Research & Therapy

Year:

2002

Language:

english

File:

PDF, 181 KB

english, 2002

12

Design and Optimisation of Bioactive Cyclic Peptides: Generation of a Down-Regulator of TNF Secretion

New, Roger, Bansal, Gurpal, Dryjska, Malgorzata, Bogus, Michal, Green, Patricia, Feldmann, Marc, Brennan, Fionula

Journal:

Year:

2014

Language:

english

File:

PDF, 906 KB

english, 2014

13

Novel biomarkers of a peripheral blood interferon signature associated with drug-naÃ¯ve early arthritis patients distinguish persistent from self-limiting disease course

Seyhan, Attila A., Gregory, Bernard, Cribbs, Adam P., Bhalara, Sundeept, Li, Yizheng, Loreth, Christine, Zhang, Ying, Guo, Yongjing, Lin, Lih-Ling, Feldmann, Marc, Williams, Lynn M., Brennan, Fionula

Journal:

Scientific Reports

Year:

2020

File:

PDF, 3.72 MB

2020

14

SIGIRR/TIR-8 is an inhibitor of toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis

Stefan K. Drexler, Philip Kong, Julia Inglis, Richard O. Williams, Cecilia Garlanda, Alberto Mantovani, Amir S. Yazdi, Fionula Brennan, Marc Feldmann, Brian M. J. Foxwell

Journal:

Arthritis & Rheumatism

Year:

2010

Language:

english

File:

PDF, 854 KB

english, 2010

15

Cytokines in autoimmunity

Fionula M Brennan, Marc Feldmann

Journal:

Current Opinion in Immunology

Year:

1996

Language:

english

File:

PDF, 609 KB

english, 1996

16

Transgenic Models for Arthritis: Useful Clues to Be Gained?

Brennan, Fionula M.

Journal:

Annals of Medicine

Year:

1996

Language:

english

File:

PDF, 356 KB

english, 1996

17

Update on cytokines in rheumatoid arthritis

Brennan, Fionula, Beech, Jonathan

Journal:

Current Opinion in Rheumatology

Year:

2007

Language:

english

File:

PDF, 105 KB

english, 2007

18

The effects of tumor necrosis factor (TNF) derivatives on TNF receptors

Henryk Tchorzewski, Krzysztof Zeman, Ewa Paleolog, Fionula Brennan, Marc Feldmann, Mel Kahan, Piotr Guga, Marek Kwinkowski, Bozena Szymanska, Joanna Jarosz, Pawel Parniewski, Eugeniusz Kocur

Journal:

Year:

1993

Language:

english

File:

PDF, 674 KB

english, 1993

19

Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-β

Martin Turner, David Chantry, Peter Katsikis, Ann Berge, Fionula M. Brennan, Marc Feldmann

Journal:

European Journal of Immunology

Year:

1991

Language:

english

File:

PDF, 506 KB

english, 1991

20

The immunoregulatory role of interleukin-10 in Crohn's disease (CD)cell cultures

James O. Lindsay, Marc Feldmann, Humphrey J. Hodgson, Fionula M. Brennan

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 188 KB

english, 2000

21

TNFα Is an Effective Therapeutic Target for Rheumatoid Arthritis

MARC FELDMANN, FIONULA M. BRENNAN, MICHAEL J. ELLIOTT, RICHARD O. WILLIAMS, RAVINDER N. MAINI

Journal:

Annals of the New York Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 386 KB

english, 1995

22

Role of pro-inflammatory cytokines in rheumatoid arthritis

Fionula M. Brennan, Ravinder N. Maini, Marc Feldmann

Journal:

Seminars in Immunopathology

Year:

1998

Language:

english

File:

PDF, 1005 KB

english, 1998

23

Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis

Cribbs, Adam P., Kennedy, Alan, Penn, Henry, Amjadi, Parisa, Green, Patricia, Read, Jordan E., Brennan, Fionula, Gregory, Bernard, Williams, Richard O.

Journal:

Arthritis & Rheumatology

Year:

2015

Language:

english

File:

PDF, 1.00 MB

english, 2015

24

Robin Callard, Andy Gearing, ,The cytokine factsbook (1994) Academic Press 1994.

Fionula M. Brennan

Journal:

Immunology Today

Year:

1995

Language:

english

File:

PDF, 137 KB

english, 1995

25

CXCR4 and vascular cell adhesion molecule 1 are key chemokine/adhesion receptors in the migration of cytokine-activated T cells

Jane Bryant, David J. Ahern, Fionula M. Brennan

Journal:

Arthritis & Rheumatism

Year:

2012

Language:

english

File:

PDF, 259 KB

english, 2012

26

Anti-TNF therapy: Where have we got to in 2005?

Marc Feldmann, Fionula M. Brennan, Brian M.J. Foxwell, Peter C. Taylor, Richard O. Williams, R.N. Maini

Journal:

Journal of Autoimmunity

Year:

2005

Language:

english

File:

PDF, 83 KB

english, 2005

27

Efficient Adenoviral Infection with Iκ Bα Reveals that Macrophage Tumor Necrosis Factor α Production in Rheumatoid Arthritis is NF-κ B Dependent

Brian Foxwell, Kylie Browne, Jan Bondeson, Chris Clarke, Rainer De Martin, Fionula Brennan and Marc Feldmann

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.51 MB

english, 1998

28

Tenosynovial Destruction of Tendons in Rheumatoid Arthritis

Jain, Abhilash, Brennan, Fionula, Nanchahal, Jagdeep

Journal:

Clinical Science

Year:

2002

Language:

english

File:

PDF, 241 KB

english, 2002

29

Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells

Cribbs, Adam P, Kennedy, Alan, Gregory, Bernard, Brennan, Fionula M

Journal:

BMC Biotechnology

Year:

2013

Language:

english

File:

PDF, 278 KB

english, 2013

30

The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: Major contributors or essential homeostatic modulators?

David J. Ahern, Fionula M. Brennan

Journal:

Immunology Letters

Year:

2011

Language:

english

File:

PDF, 362 KB

english, 2011

31

Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells

Andrew P. Cope, Deena L. Gibbons, Dan Aderka, Brian M. Foxwell, David Wallach, Ravinder N. Maini, Marc Feldmann, Fionula M. Brennan

Journal:

Year:

1993

Language:

english

File:

PDF, 784 KB

english, 1993

32

Defining Therapeutic Targets by Using Adenovirus: Blocking NF-κ B Inhibits Both Inflammatory and Destructive Mechanisms in Rheumatoid Synovium but Spares Anti-Inflammatory Mediators

Jan Bondeson, Brian Foxwell, Fionula Brennan and Marc Feldmann

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.36 MB

english, 1999

33

A novel upstream enhancer of FOXP3 , sensitive to methylation-induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells

Kennedy, Alan, Schmidt, Emily M., Cribbs, Adam P., Penn, Henry, Amjadi, Parisa, Syed, Khaja, Read, Jordan E., Green, Patricia, Gregory, Bernard, Brennan, Fionula M.

Journal:

European Journal of Immunology

Year:

2014

Language:

english

File:

PDF, 810 KB

english, 2014

34

Targeting Rheumatoid Tenosynovial Angiogenesis with Cytokine Inhibitors

Jain, Abhilash, Kiriakidis, Serafim, Brennan, Fionula, Sandison, Ann, Paleolog, Ewa, Nanchahal, Jagdeep

Journal:

Clinical Orthopaedics and Related Research®

Year:

2006

Language:

english

File:

PDF, 645 KB

english, 2006

35

Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: Involvement of phosphatidylinositol 3-kinase and nuclear factor κB pathways in tumor necrosis factor α production in rheumatoid arthritis

Fionula M. Brennan, Amanda L. Hayes, Cathleen J. Ciesielski, Patricia Green, Brian M. J. Foxwell, Marc Feldmann

Journal:

Arthritis & Rheumatism

Year:

2002

Language:

english

File:

PDF, 175 KB

english, 2002

36

The Toll-Like Receptor Adaptor Proteins MyD88 and Mal/TIRAP Contribute to the Inflammatory and Destructive Processes in a Human Model of Rheumatoid Arthritis

Sandra M. Sacre, Evangelos Andreakos, Serafim Kiriakidis, Parisa Amjadi, Anna Lundberg, Grey Giddins, Marc Feldmann, Fionula Brennan, Brian M. Foxwell

Journal:

The American Journal of Pathology

Year:

2007

Language:

english

File:

PDF, 460 KB

english, 2007

37

Resting CD4+effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function

Fionula M Brennan, Nicola MG Smith, Sally Owen, Ching Li…

Journal:

Arthritis Research & Therapy

Year:

2008

Language:

english

File:

PDF, 1.39 MB

english, 2008

38

Persistence of Collagen Type II-Specific T-Cell Clones in the Synovial Membrane of a Patient with Rheumatoid Arthritis

Marco Londei, Corinne M. Savill, Adrienne Verhoef, Fionula Brennan, Zoe A. Leech, Victor Duance, Ravinder N. Maini and Marc Feldmann

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 804 KB

english, 1989

39

Lung-marginated Monocytes Modulate Pulmonary Microvascular Injury during Early Endotoxemia

O'Dea, Kieran P., Young, Arnold J., Yamamoto, Hirotoshi, Robotham, James L., Brennan, Fionula M., Takata, Masao

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2005

Language:

english

File:

PDF, 443 KB

english, 2005

40

Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis

Debra M. Butler, Anne-Marie Malfait, Ravinder N. Maini, Fionula M. Brennan, Marc Feldmann

Journal:

European Journal of Immunology

Year:

1999

Language:

english

File:

PDF, 128 KB

english, 1999

41

Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines

Deena L. Gibbons, Martin Roweu, Andrew P. Cope, Marc Feldmann, Fionula M. Brennan

Journal:

European Journal of Immunology

Year:

1994

Language:

english

File:

PDF, 703 KB

english, 1994

42

Treating Rheumatoid Tenosynovitis with Cytokine Inhibitors

Jain, Abhilash, Brennan, Fionula, Troeberg, Linda, Nanchahal, Jagdeep

Journal:

Clinical Science

Year:

2003

Language:

english

File:

PDF, 126 KB

english, 2003

43

Invasive Potential of Human Rheumatoid Tenosynovial Cells Is in Part MT1-MMP Dependent

Abhilash Jain, Mary-Clare Miller, Linda Troeberg, Yoshifumi Itoh, Fionula Brennan, Jagdeep Nanchahal

Journal:

The Journal of Hand Surgery: British & European Volume

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

44

Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis

Andrew Foey, Patricia Green, Brian Foxwell, Marc Feldmann, Fionula Brennan

Journal:

Arthritis Research & Therapy

Year:

2001

Language:

english

File:

PDF, 597 KB

english, 2001

45

Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints

Fionula M. Brennan, Deena L. Gibbons, Andrew P. Cope, Marc Feldmann, Tracey Mitchell, Ravinder N. Maini

Journal:

European Journal of Immunology

Year:

1992

Language:

english

File:

PDF, 694 KB

english, 1992

46

The role of matrix metal loproteinases in rheumatoid tendon disease

Abhilash Jain, Fionula Brennan, Linda Troeberg, Jagdeep Nanchahal

Journal:

The Journal of Hand Surgery: British & European Volume

Year:

2002

Language:

english

File:

PDF, 525 KB

english, 2002

47

In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008

Fionula Brennan, Marc Feldmann

Journal:

Arthritis Research & Therapy

Year:

2009

Language:

english

File:

PDF, 494 KB

english, 2009

48

Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis

Abhilash Jain, Jagdeep Nanchahal, Linda Troeberg, Patricia Green, Fionula Brennan

Journal:

Arthritis & Rheumatism

Year:

2001

Language:

english

File:

PDF, 1.31 MB

english, 2001

49

132 Toll-like Receptors (TLRS) Contribute in the Inflammation and Pathogenesis of RA

Sandra Sacre, Alexandra Lo, Mino Medghalchi, Bernard Gregory, Lynn Williams, Fionula Brennan, Richard Williams, Brian Foxwell

Journal:

Year:

2007

Language:

english

File:

PDF, 47 KB

english, 2007

50

Evidence that cytokines play a role in rheumatoid arthritis

Brennan, Fionula M., McInnes, Iain B.

Journal:

Journal of Clinical Investigation

Year:

2008

Language:

english

File:

PDF, 963 KB

english, 2008

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